Novel Tools for Drug Discovery in Neurodegenerative Diseases

Explore novel tools for drug discovery in neurodegenerative diseases in this 27-minute webinar presented by Dr. Jacob McPhail, a biochemist specializing in protein complexes. Learn about the development of consistent, scalable methods to generate active neurotoxic protein aggregates in vitro, focusing on Alzheimer's and Parkinson's diseases. Discover how these new molecular tools, including fibrils of pyroglutamate Aβ, tau dGAE fragment, and co-polymer alpha-synuclein and tau fibrils, expand the range of constructs available for studying neurodegenerative diseases and facilitate drug discovery efforts. Gain insights into the common pathological mechanisms of protein aggregation leading to neuronal toxicity and plaque formation in these disorders. Understand the importance of establishing disease models that effectively mimic in vivo pathology for advancing AD/PD drug discovery.