Multifaceted Community Analyses Uncover Novel Bacterial Species in the Colorectal Tumor Niche

Explore groundbreaking research on novel bacterial species in colorectal cancer tumors through this 24-minute webinar presented by Dr. Martha Zepeda Rivera. Delve into the application of large-scale culturing techniques and bacterial single-cell whole genome sequencing to isolate three new bacterial species, including a novel Fusobacterium, from colorectal cancer tumor samples. Learn how PacBio Single Molecule Real Time (SMRT) sequencing enabled complete genome analysis, facilitating comparative genomics and identification of unique genetic factors in these tumor isolates. Gain insights into the tumor-associated microbiota's role in cancer initiation, progression, and treatment response. Discover how this research lays the foundation for future mechanistic studies to understand the capabilities and roles of these newly discovered bacterial species in the colorectal tumor niche.