Multifaceted Community Analyses Uncover Novel Bacterial Species in the Colorectal Tumor Niche

Explore groundbreaking research on novel bacterial species in colorectal cancer tumors through this 24-minute webinar presented by Dr. Martha Zepeda Rivera. Delve into the application of large-scale culturing techniques and bacterial single-cell whole genome sequencing to isolate three new bacterial species, including a novel Fusobacterium, from colorectal cancer tumor samples. Learn how PacBio Single Molecule Real Time (SMRT) sequencing enabled complete genome acquisition, facilitating comparative genomics and bioinformatic analyses to identify unique genetic factors in these tumor isolates. Gain insights into the tumor-associated microbiota's role in cancer initiation, progression, and treatment response. Discover how this research lays the groundwork for future mechanistic studies on these newly discovered bacterial species within the colorectal tumor niche.