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Dissecting the Contribution of the Repeatome to Complex Traits

Computational Genomics Summer Institute CGSI via YouTube

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Overview

Explore the impact of repetitive DNA sequences on complex human traits in this 37-minute lecture from the Computational Genomics Summer Institute. Delve into genome-wide association studies, focusing on short tandem repeats and their contributions to blood and serum traits. Examine cutting-edge research on population-specific repeat expansions and their integration with other genomic data. Learn about challenges in identifying and analyzing tandem repeats from sequencing data, and discover tools and opportunities for further investigation in this rapidly evolving field of computational genomics.

Syllabus

Introduction
Genomewide Association Studies
Single nucleotide polymorphisms
GWAS signals
Types of repeats
Human phenotypes
Lab work
Tandem repeats from sequencing
Challenges
Overlap
Ensemble TR
PopulationSpecific Expansions
concordance
integration
Jonathan Margoliage
Results
Example trait association
Challenges we still face
Conclusion
Polystyrene Repeat
Alpha Fold
Challenges and Opportunities
Tools
Conclusions

Taught by

Computational Genomics Summer Institute CGSI

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