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Explore the world of high-energy physics computing in this 24-minute EuroPython Conference talk. Dive into Ganga, a Python-based tool designed for CERN's particle physics experiments, providing a user-friendly interface for thousands of physicists to access vast computing resources. Learn how Ganga simplifies data analysis tasks, enabling seamless distribution across local machines and global computing centers. Discover the challenges faced by physicists in managing complex computer infrastructure and how Ganga addresses these issues. Gain insights into the advanced Python features, such as metaclasses and IPython integration, that power this innovative tool. Understand the intricacies of handling large files, job objects, and persistent databases in the context of particle physics research. Engage with topics like project management, output file handling, and communication strategies within the scientific community.