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Explore the intricacies of Python dependency management in this 29-minute EuroPython Conference talk. Delve into the long-standing challenge of ensuring reliable and repeatable dependency installation for Python projects. Learn how PEP 518 and the new pyproject.toml file specification have revolutionized dependency management. Discover powerful tools like Poetry, Hatch, and Pipenv that leverage this new approach. Gain insights on replacing multiple configuration files with a single pyproject.toml, understand the complexities of dependency resolution, compare different management tools, and explore alternatives like pip-tools. Additionally, learn about using pipx to isolate system-wide Python tools for enhanced project management.