Investigating Rapid Nuclear Mechanotransduction by Mapping Genome-wide Changes in Transcription

Watch a research lecture exploring groundbreaking findings on nuclear mechanotransduction and its role in cellular responses. Discover how Professor Jan Lammerding's team used PRO-seq and ATAC-seq techniques to investigate immediate transcriptome and genome organization changes following mechanical stimulation. Learn about the identification of mechanoresponsive genes activating within just 2 minutes of mechanical stretch - far faster than previously known cytoplasmic signaling cascades. Understand the implications of finding pre-positioned RNA polymerase II and pre-accessible chromatin regions, suggesting the nucleus itself plays a direct role in rapid mechanical response. Gain insights from Lammerding, a distinguished professor at Cornell University's Meinig School of Biomedical Engineering, whose pioneering work in nuclear mechanobiology has applications in muscular dystrophy, heart disease, and cancer research.