Explore pharmacokinetic concepts in this comprehensive lecture from the NIH Principles of Clinical Pharmacology Course. Delve into the fundamentals of clinical pharmacology, focusing on rational drug development and therapeutic utilization. Learn about dose-response relationships, therapeutic drug monitoring, and target concentration strategies. Examine distribution volumes, elimination half-life, and maintenance therapy using digoxin as a case study. Understand creatinine clearance equations and their importance in drug dosing. Investigate steady-state concentrations and the complexities of phenytoin kinetics. Gain insights into apparent first-order kinetics and their clinical implications. This 54-minute presentation by Dr. Juan J.L. Lertora offers a deep dive into essential pharmacokinetic principles for healthcare professionals and researchers in the field of clinical pharmacology.
Introduction to Clinical Pharmacology and Therapeutics - Pharmacokinetic Concepts - Part 2
NIH Clinical Center via YouTube
Overview
Syllabus
Clinical Pharmacology
Pharmacokinetics - Pharmacodynamics
USES OF PHARMACOKINETICS
Dose-Response Relationship
"Target concentration" strategy
FIRST DESCRIPTION OF THERAPEUTIC DRUG MONITORING
DRUG CANDIDATES FOR TDM
TARGET CONCENTRATION STRATEGY
TRADITIONAL Guidelines for DIGOXIN Levels
SURVIVAL as a function of DIGOXIN LEVEL measured after 1 Month Rx
3 DISTRIBUTION VOLUMES
INITIAL DIGITALIZATION
DISTRIBUTION DELAYS ONSET of DIGOXIN Chronotropic Action
ELIMINATION HALF-LIFE
ELIMINATION PARAMETERS
MAINTENANCE DIGOXIN THERAPY
CUMULATION FACTOR
ELIMINATION RATE CONSTANT
LOADING & MAINTENANCE DOSES
CREATININE CLEARANCE EQUATION
MDRD Study Equation
CKD-EPI Collaboration Equation
STEADY STATE CONCENTRATION
PHENYTOIN KINETICS in Normal Subjects
STEADY STATE EQUATIONS
RELATIONSHIP OF PLASMA LEVEL TO PHENYTOIN DOSE
PATIENT WHO BECAME TOXIC ON A PHENYTOIN DOSE OF 300 mg/day
BASIS OF APPARENT FIRST-ORDER KINETICS
Taught by
NIH Clinical Center
