Introduction to Clinical Pharmacology and Therapeutics - Part 1: Overview of Clinical Pharmacology

Explore the fundamentals of clinical pharmacology in this introductory lecture by Dr. Juan J.L. Lertora, part of the NIH Principles of Clinical Pharmacology Course. Gain insights into clinical pharmacology as a translational scientific discipline focused on rational drug development and therapeutic utilization. Delve into topics such as the principles of clinical pharmacology, founders of American clinical pharmacology, professional goals of clinical pharmacologists, and the impact of genetic polymorphisms on drug exposure. Examine adverse drug reactions, genetics in severe drug toxicity, and the consequences of historical drug crises like thalidomide. Learn about the phases of pre-marketing drug development, drug repurposing, and novel FDA-approved indications for repurposed drugs. This comprehensive overview provides a solid foundation for understanding the critical role of clinical pharmacology in modern medicine and drug development.