Hurdles and High Resolution of Spatial Proteomics in the Study of the Alloimmune Microenvironment in Liver Transplant Rejection

Explore the challenges and advancements in spatial proteomics for studying the alloimmune microenvironment in liver transplant rejection through this 20-minute webinar presented by Arianna Barbetta, MD. Delve into the complexities of acute T-cell mediated rejection (TCMR) in liver transplant recipients and discover how cutting-edge spatial single-cell technologies like Imaging Mass Cytometry (IMC) are revolutionizing our understanding of immune cell interactions. Learn about the hurdles in analyzing high-dimensional data, including image artifacts and cell classification errors, and gain insights into the computational and immunological expertise required to meaningfully characterize immune-rich microenvironments. Understand the potential of these advanced techniques in identifying rare cell phenotypes and unraveling the immunological factors driving TCMR and its recurrence in liver transplantation.