Genomics and Transcriptomics of Heart Disease

Explore the intricate world of cardiac genomics and transcriptomics in this 49-minute lecture by Dr. Igor Efimov, Professor of Biomedical Engineering and Medicine at Northwestern University. Delve into the dynamic transcriptional activity of promoters and enhancers to gain a deeper understanding of heart failure and heart disease pathogenesis. Learn how regulatory elements are alternatively transcribed in different heart regions, comparing healthy and failing hearts, as well as ischemic and non-ischemic heart failure. Discover the enrichment of cardiac-disease-related single nucleotide polymorphisms (SNPs) in transcriptional regulatory elements and their potential impact on allele-specific transcription factor binding. Gain insight into the open-source heart CAGE atlas, a valuable resource for the cardiovascular community in understanding cardiac gene regulatory networks and their role in cardiovascular disease and therapy. This lecture is part of the Monthly Seminar on Physical Genomics, a public lecture series sponsored by the Center for Physical Genomics at Northwestern University, the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants.