Epigenomic Landscape of Retrotransposon Expression in Senescence and Neurodegeneration

Explore the fascinating world of transposable elements and their impact on aging and neurodegeneration in this 58-minute lecture by John Sedivy, Director of the Center on the Biology of Aging at Brown University. Delve into the complex relationship between retrotransposons and cellular senescence, focusing on LINE-1 retrotransposons and their role in activating type-I interferon responses. Examine how retrotransposon activation contributes to age-associated inflammation and the senescence-associated secretory phenotype (SASP). Learn about cutting-edge research using long-read DNA and RNA sequencing to identify activated elements in senescent cells and Alzheimer's disease brain. Gain insights into recent clinical trials exploring the potential of reverse transcriptase inhibitors in treating neurodegenerative diseases. Discover the groundbreaking work of John Sedivy, including his contributions to mammalian genetics, cell cycle control, and the development of novel techniques for studying cellular senescence and aging.