Epigenetic Aging Studies in Mammals - Universal DNA Methylation Clocks and Lifespan

Explore a 30-minute webinar on epigenetic aging studies in mammals presented by Dr. Steve Horvath, a renowned expert in aging research, epidemiology, and epigenetics. Delve into the development of universal mammalian epigenetic clocks and their applications in measuring age across species. Learn about the strong association between DNA methylation levels and maximum lifespan in mammals. Discover how these epigenetic clocks can be utilized in various research settings, including in vitro studies, animal models, and human clinical trials. Gain insights into the role of DNA methylation in vertebrate development and disease, the accuracy of epigenetic clocks across different species, and the relationship between age-related conditions and epigenetic age acceleration in various tissues. Examine the effects of sex on epigenetic age acceleration and explore second-generation epigenetic clocks such as DNAM PhenoAge and GrimAge. Understand the implications of these findings for human anti-aging studies and their potential as surrogate endpoints in clinical research.