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Epigenetic Aging Studies in Mammals - Universal DNA Methylation Clocks and Lifespan
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- 1 Intro
- 2 Cytosine DNA methylation plays an important role in development and disease of vertebrates
- 3 How many probes apply to different phylogenetic orders?
- 4 70% of CpG probes map to orthologous genes in humans
- 5 Over 10k tissues from 175 species from many phylogenetic orders (red and blue)
- 6 Epigenetic clocks for mammals
- 7 Highly accurate epigenetic clocks across bat species (Jerry Wilkinson, Joseph Zoller)
- 8 Highly accurate epigenetic clocks in pure dog breeds (Elaine Ostrander, Andrew Hogan)
- 9 Universal DNA methylation age across mammalian tissues
- 10 Central question of biology: Why do similar species, such as mammals, have markedly different maximum lifespans?
- 11 Age related conditions versus epigenetic age acceleration in different tissues
- 12 Effect of sex on epigenetic age acceleration in different tissues
- 13 Second generation epigenetic clocks: DNAM PhenoAge and GrimAge
- 14 Meta analysis for the hazard ratio associated with all-cause mortality
- 15 Interpreting the hazard ratio from a Cox regression model of GrimAge
- 16 Qualifying GrimAge as surrogate endpoint for human anti-aging studies.
