Completed
Cytosine DNA methylation plays an important role in development and disease of vertebrates
Class Central Classrooms beta
YouTube videos curated by Class Central.
Classroom Contents
Epigenetic Aging Studies in Mammals - Universal DNA Methylation Clocks and Lifespan
Automatically move to the next video in the Classroom when playback concludes
- 1 Intro
- 2 Cytosine DNA methylation plays an important role in development and disease of vertebrates
- 3 How many probes apply to different phylogenetic orders?
- 4 70% of CpG probes map to orthologous genes in humans
- 5 Over 10k tissues from 175 species from many phylogenetic orders (red and blue)
- 6 Epigenetic clocks for mammals
- 7 Highly accurate epigenetic clocks across bat species (Jerry Wilkinson, Joseph Zoller)
- 8 Highly accurate epigenetic clocks in pure dog breeds (Elaine Ostrander, Andrew Hogan)
- 9 Universal DNA methylation age across mammalian tissues
- 10 Central question of biology: Why do similar species, such as mammals, have markedly different maximum lifespans?
- 11 Age related conditions versus epigenetic age acceleration in different tissues
- 12 Effect of sex on epigenetic age acceleration in different tissues
- 13 Second generation epigenetic clocks: DNAM PhenoAge and GrimAge
- 14 Meta analysis for the hazard ratio associated with all-cause mortality
- 15 Interpreting the hazard ratio from a Cox regression model of GrimAge
- 16 Qualifying GrimAge as surrogate endpoint for human anti-aging studies.
