Challenges and Opportunities at the Nexus of Synthetic Biology, Machine Learning, and Automation
Georgia Tech Research via YouTube
Overview
Syllabus
Intro
Microelectronics vs. Biotechnology
What is Synthetic Biology?
Automated Protein Engineering: Fully Automated & HT Synthesis of TALENS
Preventing Transmission of Mitochondrial Diseases
Lycopene Pathway as a Test Case
Automated Cellular Engineering: east strain development via RNAi-assisted Genome Evolution
DOE Center for Advanced Bioenergy & Bioproducts Innovation
Vision: Develop an Automated Cellular Engineering (ACE) Platform
Multi-functional Genome-wide CRISPR System (MAGIC)
3. CRISPR/HDR Assisted Genome- scale Engineering (CHANGE)
Editing Efficiencies and Validation of CHANGE
Genome Editing with Single Nucleotide Precision
Three Main Types of Catalysis
Biocatalysis vs. Chemical Catalysis I
Combining Biocatalysis and Chemical Catalysis
Enzymatic Reduction of E/Z Olefins
Concept: Isomerization and Reduction
Tandem vs Sequential
Proposed Mechanism
Condition Optimization
Substrate Scope
Molecule Maker Lab Institute (an NSF AI Research Institute)
Summary
Taught by
Georgia Tech Research