Pirating Proteins to Attack the Surfaceome - Engineering Tools for Cell Surface Proteome Analysis

Watch a 54-minute seminar from the Broad-MIT Chemical Biology series where Jim Wells presents "Pirating Proteins to Attack the Surfaceome," exploring innovative approaches to targeting cancer through cell surface proteins. Learn about engineered proteins and chemical tools developed for identifying surface-level proteins and their disease-associated modifications. Discover novel antibody selection methods that enable more selective and safer cancer cell targeting, as well as new protein degraders inspired by intracellular targeted protein degradation (iTPD) techniques adapted for extracellular applications (eTPD). Gain insights into how these advances in understanding and manipulating the surfaceome - a crucial hub for cellular communication - are creating new possibilities for both small molecule and biologic drug development.