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Explore protein quality control mechanisms in this comprehensive lecture from the 9th MACS Colloquium at Kyoto University Graduate School of Science. Professor Kazutoshi Mori delves into fundamental concepts starting with cell biology basics, protein structure and function, and protein quality assessment. Learn about protein self-organization processes, endoplasmic reticulum stress response mechanisms, molecular chaperones and their evolutionary significance, and how disruptions in ER stress response lead to various pathological conditions. Through detailed explanations across seven key topics, gain deep insights into cellular protein management systems and their importance in maintaining cellular health.