小胞体ストレス応答：タンパク質の品質を管理する細胞応答

Learn about cellular protein quality control and endoplasmic reticulum stress response in this 39-minute lecture from the 5th Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium. Explore how cells, the basic units of life that number 60 trillion in the human body, contain various organelles including the endoplasmic reticulum - a protein manufacturing factory. Discover the critical role of proteins in living organisms, illustrated through the example of diabetes and insulin function. Understand how the endoplasmic reticulum manages protein folding and quality control, and learn about the groundbreaking discovery of cellular restoration mechanisms when protein production becomes compromised. Professor Kazutoshi Mori explains these complex biological processes in accessible terms, sharing insights from his 29 years of research including the first-ever discovery of sensor molecules that detect deteriorating conditions within the endoplasmic reticulum.