Medicinal chemistry is concerned with the discovery, development and confirmation of drugs and the study of the way drugs work at the molecular level. Medicinal chemistry is based on chemistry and biology, involving medical science and pharmacy and other disciplines. It is a comprehensive discipline related to the discovery and invention of new drugs, the synthesis of chemical drugs, the clarification of the nature of chemical drugs, the chemical changes in the process of drugs in vivo, and the study of the law of interaction between drug molecules and biological macromolecules. It is an important leading discipline in the field of pharmacy.
Overview
Syllabus
- Chapter 1. Introduction
- 1.1 Introduction
- 1.2 The relationship between Medicinal Chemistry and other disciplines
- 1.3 Achievements of Medicinal Chemistry
- 1.4 Challenges and Opportunities for innovative drug research
- 1.5 Summarize
- Chapter 2. Sedative-Hypnotics
- 2.1Sedative-Hypnotics-1
- 2.2 Sedative-Hypnotics-2
- 2.3 Antiepileptics
- Chapter 3. Psychoterapeutic Drugs
- 3.1 Introduction
- 3.2 Antipsychotic Drugs
- 3.3 Antidepressive Drugs
- Chapter 4. Analgesics
- 4.1 Introduction
- 4.2 Structure and properties of Morphine
- 4.3 The side effects and abuse of Morphine
- 4.4 Structural modification of Morphine_1
- 4.5 Structural modification of Morphine_2
- 4.6 Synthetic Analgesics
- 4.7 Conclusion
- Chapter 5. Nonsteroidal Antiinflammatory Drugs
- 5.1 The Discovery of NSAIDs
- 5.2 Antipyretic Analgesics
- 5.3 Target of NSAIDs
- 5.4 Nonsteroidal Antiinflammatory Drugs
- 5.5 Selective Cycloxygenase-2 Inhibitors
- 5.6 Agents used to treat gout
- Chapter 6. Cholinergic Agents and Anticholinergic Agents
- 6.1Introduction
- 6.2 Cholinergic Agents
- 6.3 Anticholinergic Agents
- Chapter 7. Antiallergic Agents
- 7.1 Histamine and histamine receptors
- 7.2 Classical H1-receptor antagonists
- 7.3 Nonsedative H1-receptor antagonists
- 7.4 Structure-activity relationship of histamine H1-receptor antagonists
- Chapter 8. Digestive System Agents
- 8.1Introduction
- 8.2 Antiulcer drug
- 8.3 Discovery of histamine H2-receptor antagonists
- 8.4 Histamine H2-receptor antagonist
- 8.5 Proton pump inhibitor-1
- 8.6 Proton pump inhibitor-2
- Chapter 9. Drugs affecting adrenergic receptor
- 9.1 Introduction
- 9.2 Adrenergic Agents
- 9.3 Selective α-Receptor Agonists
- 9.4 Selective β-Receptor Agonists
- 9.5 Structure-activity relationship of Adrenergic Agents
- 9.6α-Receptor Blockers
- 9.7 β-Receptor Blockers
- 9.8 Conclusion
- Chapter 10. Antihypertensive Agents and Diuretics
- 10.1Drugs acting on the sympathetic nervous system
- 10.2 angiotensin converting enzyme (ACE) inhibitors
- 10.3 Angiotensin receptor (AII) antagonists
- 10.4 Calcium channel blockers
- Chapter 11. Plasma Lipids regulators
- 11.1 Chemistry and biochemistry of Plasma Lipids
- 11.2 HMG-coA reductase inhibitors
- 11.3 Drugs that affect cholesterol and triglyceride metabolism
- 11.4 Niacin and other drugs
- Chapter 12. Antibiotics
- 12.1 Introduction
- 12.2 β-lactam antibiotics
- 12.3 tetracycline antibiotics
- 12.4 aminoglycoside antibiotics
- 12.5 macrolides antibiotics
- 12.6 chloromycetin series antibiotics
- 12.7 Conclusion
- Chapter 13. Synthetic antibacterial agents
- 13.1Synthetic antibacterial agents-1
- 13.2 Synthetic antibacterial agents-2
- 13.3 Synthetic antibacterial agents-3
- Chapter 14. Antiviral Agents
- 14.1Introduction
- 14.2 Viruses and antiviral drugs
- 14.3 drugs that inhibit viral replication-1
- 14.4 drugs that inhibit viral replication-2
- 14.5 Antiretroviral Agents
- 14.6 Conclusion
- Chapter 15. Anticancer Drugs
- 15.1 Introduction
- 15.2 Drugs directly acting on DNA
- 15.3 Drugs interfering with DNA synthesis
- 15.4 Drugs acting on protein synthesis and function
- 15.5 Agents inhibiting on cancer protein kinase ( targeted drugs)
Taught by
Xiaoke Guo
