Learn about immunogene therapy through a comprehensive course covering five major areas: cytokines, antibody drugs, vaccines, cell therapy, and gene therapy. Explore the fundamentals of cytokines and their various types, followed by detailed study of antibody medications including molecular targeting antibodies, antibody-drug conjugates, and checkpoint inhibitors targeting PD-1 and CTLA-4. Master the principles of different vaccine types, including dendritic cell-based, vector-based, peptide-based, personalized neoantigen-based, and exosome-based tumor vaccines, along with HBV infection immunotherapy. Delve into cellular therapy focusing on CAR-T cells, their tumor antigens, chemotaxis, tumor microenvironment remodeling, resistance capabilities, and NK cell therapy. Conclude with gene therapy fundamentals, covering various gene transfer methods (physical and chemical), viral vectors (retroviral, adenoviral, lentiviral), and therapeutic strategies.
Overview
Syllabus
- 第一章 细胞因子
- 1.1 细胞因子基本介绍
- 1.2 常见细胞因子(一)
- 1.3 常见细胞因子(二)
- 第二章 抗体药物
- 2.1 抗体药物基本知识
- 2.2 抗体药物的分类
- 2.3 分子靶向抗体药物
- 2.4 抗体偶联药物
- 2.5 靶向免疫检查点PD-1类抗体药物
- 2.6 靶向免疫检查点CTLA-4抗体药物
- 2.7 多功能抗体药物
- 2.8 免疫系统、感染、心血管疾病治疗中的抗体药物
- 2.9 新型小分子抗体药物
- 第三章 疫苗
- 3.1 以树突状细胞为基础的肿瘤疫苗
- 3.2 以载体抗原为基础的肿瘤疫苗
- 3.3 以多肽为基础的肿瘤疫苗
- 3.4 以个体化新抗原为基础的肿瘤疫苗
- 3.5 以外泌体为基础的肿瘤疫苗
- 3.6 HBV感染的免疫调节机制及其常用的动物模型
- 3.7 HBV感染的免疫治疗学策略
- 第四章 细胞治疗
- 4.1 CAR-T细胞
- 4.2 CAR-T细胞 肿瘤抗原
- 4.3 CAR-T细胞 趋化
- 4.4 CAR-T细胞 重塑肿瘤微环境
- 4.5 CAR-T细胞 抵抗能力
- 4.6 NK细胞治疗
- 第五章 基因治疗
- 5.1 基因治疗概念
- 5.2 基因转移方法
- 5.3 基因转移方法 物理方法
- 5.4 基因转移方法 化学方法
- 5.5 逆转录病毒
- 5.6 腺病毒
- 5.7 慢病毒
- 5.8 策略
- 5.9 基因干扰
- 期末考试
Taught by
Jian zhang, , and