This free course, Cell signalling, explains the general principles of signal transduction and specifically, how even the simplest organisms can detect and respond to events in their ever-changing environment.
Overview
Syllabus
- Introduction
- Learning outcomes
- 1 General principles of signal transduction
- 1 General principles of signal transduction
- 1.1 Introduction
- 1.2 Extracellular signals can act locally or at a distance
- 1.2.1 Cell–cell contact-dependent signalling
- 1.2.2 Cell–cell signalling via secreted molecules
- 1.3 Most receptors are on the cell surface
- 1.4 Cellular responses are diverse
- 1.5 Signal transduction mechanisms
- 1.6 Signalling proteins can act as molecular switches
- 1.7 Localization of signalling proteins
- 1.8 Protein–protein interactions in signal transduction
- 1.9 Summary
- 2 Receptors and their ligands
- 2 Receptors and their ligands
- 2.1 Introduction
- 2.2 Receptor specificity
- 2.3 Receptor activation
- 2.3.1 Ion-channel receptors
- 2.3.2 Seven-helix transmembrane (7TM) receptors
- 2.3.3 Receptors with intrinsic enzymatic activity
- 2.3.4 Recruiter receptors
- 2.4 Receptor inactivation
- 2.5 Intracellular receptors
- 2.6 Summary
- 3 Intracellular signalling components
- 3 Intracellular signalling components
- 3.1 Introduction
- 3.2 Trimeric G proteins
- 3.3 Lipid-modifying enzymes
- 3.3.1 Phosphatidylinositol 3-kinase (PI 3-kinase)
- 3.3.2 Phospholipase C (PLC)
- 3.4 Second messengers
- 3.4.1 Calcium ions
- 3.4.2 Cyclic AMP
- 3.4.3 Cyclic GMP
- 3.5 Monomeric G proteins
- 3.6 Protein kinases
- 3.6.1 The MAP kinase pathway
- 3.6.2 The JAK–STAT pathway
- 3.7 Protein phosphatases
- 3.8 Activation of transcription factors
- 3.9 Summary
- 4 Glucose metabolism: an example of integration of signalling pathways
- 4 Glucose metabolism: an example of integration of signalling pathways
- 4.1 Glucose metabolism
- 4.2 Summary
- Conclusion
- References
- Acknowledgements
