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ORCAS trial
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Update on Cryptococcal Disease in HIV-Infected Patients - Lecture 7
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- 1 Intro
- 2 Overview
- 3 Laboratory-confirmed cryptococcosis in SA GERMS
- 4 Burden of cryptococcal meningitis (Gauteng Province)
- 5 Case fatality rate: South Africa
- 6 CrAg Lateral Flow Assay
- 7 Implementation and challenges
- 8 ORCAS trial
- 9 Open label RCT in Vietnam (n = 299)
- 10 WHO Guidelines 2011
- 11 Case scenario
- 12 IRIS meta-analysis
- 13 Trials of ART timing in cryptococcal meningitis prior to the COAT trial
- 14 Randomized Strategy Trial Cryptococcal Optimal ART Timing (COAT) Trial Uganda and South Africa
- 15 COAT Trial Treatment for Cryptococcal Meningitis
- 16 Causes of death
- 17 Early ART initiation particularly harmful if
- 18 What was cause of excess mortality with early ART in COAT/Zimbabwe trial?
- 19 Day 14 CSF findings
- 20 Conclusions (1)
- 21 Conclusions (2)
- 22 Acknowledgements
