Update on Cryptococcal Disease in HIV-Infected Patients - Lecture 7

Update on Cryptococcal Disease in HIV-Infected Patients - Lecture 7

Harvard University via YouTube Direct link

Burden of cryptococcal meningitis (Gauteng Province)

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4 of 22

Burden of cryptococcal meningitis (Gauteng Province)

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Classroom Contents

Update on Cryptococcal Disease in HIV-Infected Patients - Lecture 7

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  1. 1 Intro
  2. 2 Overview
  3. 3 Laboratory-confirmed cryptococcosis in SA GERMS
  4. 4 Burden of cryptococcal meningitis (Gauteng Province)
  5. 5 Case fatality rate: South Africa
  6. 6 CrAg Lateral Flow Assay
  7. 7 Implementation and challenges
  8. 8 ORCAS trial
  9. 9 Open label RCT in Vietnam (n = 299)
  10. 10 WHO Guidelines 2011
  11. 11 Case scenario
  12. 12 IRIS meta-analysis
  13. 13 Trials of ART timing in cryptococcal meningitis prior to the COAT trial
  14. 14 Randomized Strategy Trial Cryptococcal Optimal ART Timing (COAT) Trial Uganda and South Africa
  15. 15 COAT Trial Treatment for Cryptococcal Meningitis
  16. 16 Causes of death
  17. 17 Early ART initiation particularly harmful if
  18. 18 What was cause of excess mortality with early ART in COAT/Zimbabwe trial?
  19. 19 Day 14 CSF findings
  20. 20 Conclusions (1)
  21. 21 Conclusions (2)
  22. 22 Acknowledgements

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