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Temporo-spatial action of Hla in sepsis
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Classroom Contents
Understanding Pathogen Biology - Key New Therapies
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- 1 Intro
- 2 Disclosure
- 3 Human sepsis pathogens and their toxins
- 4 Anatomy of a pathogen: complexity of virulence
- 5 Staphylococcus aureus a-toxin (Hla) in sepsis
- 6 A Disintegrin and Metalloprotease 10 (ADAM10) is the cellular receptor for Hla
- 7 Hla injures the endothelial barrier
- 8 Host response to endothelial injury
- 9 Hla utilizes ADAM 10 to block platelet function
- 10 Platelet ADAM 10 knockout mitigates sepsis- associated lung injury
- 11 Platelet sensitivity to Hla enhances neutrophil inflammatory cytokine production
- 12 Platelet-myeloid double ADAM 10 knockout protects against multi-organ injury in sepsis
- 13 Protection against multi-organ toxin injury is associated with sepsis survival
- 14 Temporo-spatial action of Hla in sepsis
- 15 Can highly targeted approaches be successful?
- 16 A proposed model for focused interventions
- 17 Acknowledgements
