Understanding Pathogen Biology - Key New Therapies

Understanding Pathogen Biology - Key New Therapies

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Staphylococcus aureus a-toxin (Hla) in sepsis

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5 of 17

Staphylococcus aureus a-toxin (Hla) in sepsis

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Understanding Pathogen Biology - Key New Therapies

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  1. 1 Intro
  2. 2 Disclosure
  3. 3 Human sepsis pathogens and their toxins
  4. 4 Anatomy of a pathogen: complexity of virulence
  5. 5 Staphylococcus aureus a-toxin (Hla) in sepsis
  6. 6 A Disintegrin and Metalloprotease 10 (ADAM10) is the cellular receptor for Hla
  7. 7 Hla injures the endothelial barrier
  8. 8 Host response to endothelial injury
  9. 9 Hla utilizes ADAM 10 to block platelet function
  10. 10 Platelet ADAM 10 knockout mitigates sepsis- associated lung injury
  11. 11 Platelet sensitivity to Hla enhances neutrophil inflammatory cytokine production
  12. 12 Platelet-myeloid double ADAM 10 knockout protects against multi-organ injury in sepsis
  13. 13 Protection against multi-organ toxin injury is associated with sepsis survival
  14. 14 Temporo-spatial action of Hla in sepsis
  15. 15 Can highly targeted approaches be successful?
  16. 16 A proposed model for focused interventions
  17. 17 Acknowledgements

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