The Laws of Sensitivity for Small Nonequilibrium Systems

The Laws of Sensitivity for Small Nonequilibrium Systems

Santa Fe Institute via YouTube Direct link

Laws of sensitivity for small systems

1 of 23

1 of 23

Laws of sensitivity for small systems

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The Laws of Sensitivity for Small Nonequilibrium Systems

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  1. 1 Laws of sensitivity for small systems
  2. 2 At equilibrium, physics provides powerful tools to relate sensitivity (response to a perturbation) to system Structure
  3. 3 Binding to hemoglobin
  4. 4 Hill's explanation • Binding curve shape can be explained by multiple oxygen hemoglobin (Hil 1910)
  5. 5 A simple equilibrium law
  6. 6 Alienagerie of nonequilibrium sensitivity mechanisms...
  7. 7 Chemotaxis in E. coli
  8. 8 Quantifying sensitivity
  9. 9 Counting bound CheY-P...
  10. 10 Two sides of an equation
  11. 11 Kinetic schemes
  12. 12 Equilibrium vs. nonequilibrium
  13. 13 A common picture
  14. 14 Back to the flagellar motor
  15. 15 Tu's motor model
  16. 16 Key tool underlying results • There is an exact, algebraic expression for the nonequilibrium steady state probabilities in terms of transition rates. (Markov chain tree theorem)
  17. 17 Types of perturbations . Parameterize the transition rates like this
  18. 18 Tiuctuations determine sensitivity to vertex perturbations
  19. 19 Revisiting the flagellar motor
  20. 20 Nested hysteresis
  21. 21 Where to next?
  22. 22 Driving forces bound sensitivity to (symmetric) edge perturbations
  23. 23 Unifying the menagerie

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