Stroke and Dementia: Causes, Treatments, and New Research - Lecture 5/24/23

Stroke and Dementia: Causes, Treatments, and New Research - Lecture 5/24/23

Mary Greeley Medical Center via YouTube Direct link

Outline

2 of 25

2 of 25

Outline

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Stroke and Dementia: Causes, Treatments, and New Research - Lecture 5/24/23

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  1. 1 Intro
  2. 2 Outline
  3. 3 What is a stroke?
  4. 4 Sloppy VEN diagrams for stroke and small stroke
  5. 5 Case 2
  6. 6 Questions on Case 1 and 2
  7. 7 Meet the neurovascular unit and proposed role in small vessel disease
  8. 8 Clinical Definitions; many pathologies causing the clinical condition
  9. 9 Many causes of dementia and some reversible
  10. 10 The Ugly Pathological Reality
  11. 11 Historical tidbits
  12. 12 Some historical wrinkles
  13. 13 Genes and amyloid and tau
  14. 14 Treatment: Bring on the mABS Monoclonal antibodies to amyloid parts
  15. 15 What is Crazy new in stroke and dementi
  16. 16 Old Mice do not recover from MCA stroke as well as Young Mice. Their microbiomes are also different.
  17. 17 Better Microbiome will reduce stroke damage. SCFA (inulin) helps.
  18. 18 Modify genes to modify aging? Stem Cel
  19. 19 Drug infusion to modify genes.
  20. 20 a. Sleep and the benefit of Glymphatic Drainage
  21. 21 b. Sleep (SWS) promotes Glymphatic Drain but SWS declines with age
  22. 22 3. Block orexin and improve sleep and drainage and memory
  23. 23 RNA wild card with Neurovascular Unit: mRNA, tRNA, rRNA + lots of other RNA par
  24. 24 Variety of RNA
  25. 25 What is Reality

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