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Stroke and Dementia: Causes, Treatments, and New Research - Lecture 5/24/23
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- 1 Intro
- 2 Outline
- 3 What is a stroke?
- 4 Sloppy VEN diagrams for stroke and small stroke
- 5 Case 2
- 6 Questions on Case 1 and 2
- 7 Meet the neurovascular unit and proposed role in small vessel disease
- 8 Clinical Definitions; many pathologies causing the clinical condition
- 9 Many causes of dementia and some reversible
- 10 The Ugly Pathological Reality
- 11 Historical tidbits
- 12 Some historical wrinkles
- 13 Genes and amyloid and tau
- 14 Treatment: Bring on the mABS Monoclonal antibodies to amyloid parts
- 15 What is Crazy new in stroke and dementi
- 16 Old Mice do not recover from MCA stroke as well as Young Mice. Their microbiomes are also different.
- 17 Better Microbiome will reduce stroke damage. SCFA (inulin) helps.
- 18 Modify genes to modify aging? Stem Cel
- 19 Drug infusion to modify genes.
- 20 a. Sleep and the benefit of Glymphatic Drainage
- 21 b. Sleep (SWS) promotes Glymphatic Drain but SWS declines with age
- 22 3. Block orexin and improve sleep and drainage and memory
- 23 RNA wild card with Neurovascular Unit: mRNA, tRNA, rRNA + lots of other RNA par
- 24 Variety of RNA
- 25 What is Reality
