Mechano-Epigenetics for Cell Engineering: Biophysical Regulation and Applications

Mechano-Epigenetics for Cell Engineering: Biophysical Regulation and Applications

Center for Physical Genomics and Engineering via YouTube Direct link

Conclusions

19 of 19

19 of 19

Conclusions

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Classroom Contents

Mechano-Epigenetics for Cell Engineering: Biophysical Regulation and Applications

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  1. 1 Symposium on Physical Genomics April 21, 2023
  2. 2 Cell and Tissue Engineering
  3. 3 Biophysical Regulation of Epigenetic State?
  4. 4 Mechanotransduction to Epigenetic Modulation
  5. 5 Cell Differentiation and Reprogramming
  6. 6 Nuclear Shape Regulates AcH3 and H3K4me2/3
  7. 7 Reduction of Intracellular Tension Enhances Reprogramming Efficiency
  8. 8 Synergistic Effects of Tension Reduction and Reprogramming Factors
  9. 9 Increases Chromatin Opening
  10. 10 Mechanical Loading on Cell and Nucleus
  11. 11 Single Cell Deformation Microfluidic Platform
  12. 12 Squeezing Decreased Cell Stiffness
  13. 13 Nucleus Deformation Enhanced Neuronal Gene Activation
  14. 14 Nucleus Deformation Decreased H3K9me3
  15. 15 Nuclear Deformation Increases Chromatin Accessibility at the Promoter of Neuronal Genes
  16. 16 Biophysical vs Chemical Effects
  17. 17 Squeezing Caused Partial Disassembly and Wrinkling of Nuclear Lamina
  18. 18 Squeezing Effects on Different Cell Types
  19. 19 Conclusions

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