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Reduction of Intracellular Tension Enhances Reprogramming Efficiency
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Classroom Contents
Mechano-Epigenetics for Cell Engineering: Biophysical Regulation and Applications
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- 1 Symposium on Physical Genomics April 21, 2023
- 2 Cell and Tissue Engineering
- 3 Biophysical Regulation of Epigenetic State?
- 4 Mechanotransduction to Epigenetic Modulation
- 5 Cell Differentiation and Reprogramming
- 6 Nuclear Shape Regulates AcH3 and H3K4me2/3
- 7 Reduction of Intracellular Tension Enhances Reprogramming Efficiency
- 8 Synergistic Effects of Tension Reduction and Reprogramming Factors
- 9 Increases Chromatin Opening
- 10 Mechanical Loading on Cell and Nucleus
- 11 Single Cell Deformation Microfluidic Platform
- 12 Squeezing Decreased Cell Stiffness
- 13 Nucleus Deformation Enhanced Neuronal Gene Activation
- 14 Nucleus Deformation Decreased H3K9me3
- 15 Nuclear Deformation Increases Chromatin Accessibility at the Promoter of Neuronal Genes
- 16 Biophysical vs Chemical Effects
- 17 Squeezing Caused Partial Disassembly and Wrinkling of Nuclear Lamina
- 18 Squeezing Effects on Different Cell Types
- 19 Conclusions
