New Approaches to Vaccine Development for TB and HIV

New Approaches to Vaccine Development for TB and HIV

Harvard University via YouTube Direct link

2 classes of successful, licensed vaccines

2 of 14

2 of 14

2 classes of successful, licensed vaccines

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New Approaches to Vaccine Development for TB and HIV

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  1. 1 Intro
  2. 2 2 classes of successful, licensed vaccines
  3. 3 Liposomes: the prototypical particulate delivery system
  4. 4 A strategy for selectively stable lipid nanoparticles: interbilayer-crosslinked multilamellar vesicles (CMV)
  5. 5 (1) Stabilized lipid capsules deliver antigen to lymph node cells more efficiently than soluble or liposomal vaccines
  6. 6 ICMV nanocapsules elicit long-lived, high avidity humoral responses using low doses of antigen
  7. 7 Needle-free mucosal vaccination with ICMVS
  8. 8 Establishment of large mucosa-localized effector memory T- cell populations
  9. 9 Vaccination: Location, location, location
  10. 10 A clinically validated strategy for LN targeting: sentinel lymph node mapping
  11. 11 albumin hitch-hiking keeps CpG at local immune induction site avoiding systemic inflammation
  12. 12 Applying the amphiphile vaccine to HIV Designing long peptide antigens to constrain viral fitness
  13. 13 lymph node targeting amphiphiles as a strategy to maximize the efficacy and safety of a sector peptide-based vaccine
  14. 14 Acknowledgments

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