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Intro
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New Approaches to Vaccine Development for TB and HIV
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- 1 Intro
- 2 2 classes of successful, licensed vaccines
- 3 Liposomes: the prototypical particulate delivery system
- 4 A strategy for selectively stable lipid nanoparticles: interbilayer-crosslinked multilamellar vesicles (CMV)
- 5 (1) Stabilized lipid capsules deliver antigen to lymph node cells more efficiently than soluble or liposomal vaccines
- 6 ICMV nanocapsules elicit long-lived, high avidity humoral responses using low doses of antigen
- 7 Needle-free mucosal vaccination with ICMVS
- 8 Establishment of large mucosa-localized effector memory T- cell populations
- 9 Vaccination: Location, location, location
- 10 A clinically validated strategy for LN targeting: sentinel lymph node mapping
- 11 albumin hitch-hiking keeps CpG at local immune induction site avoiding systemic inflammation
- 12 Applying the amphiphile vaccine to HIV Designing long peptide antigens to constrain viral fitness
- 13 lymph node targeting amphiphiles as a strategy to maximize the efficacy and safety of a sector peptide-based vaccine
- 14 Acknowledgments
