Individual-level Tissue-Specific Imputed Transcriptomes in Drug Target Prioritization and Disease Risk Prediction

Individual-level Tissue-Specific Imputed Transcriptomes in Drug Target Prioritization and Disease Risk Prediction

Broad Institute via YouTube Direct link

Intro

1 of 11

1 of 11

Intro

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Individual-level Tissue-Specific Imputed Transcriptomes in Drug Target Prioritization and Disease Risk Prediction

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  1. 1 Intro
  2. 2 Introduction and Background
  3. 3 Trait-relevant tissues and transcriptome imputation
  4. 4 Prioritize druggable genes for phenotypes of interest
  5. 5 Joint analysis of TWAS and co-localization
  6. 6 Gene expression-based risk prediction
  7. 7 Analysis overview
  8. 8 Polygenic Risk Score
  9. 9 Risk discrimination and group stratification
  10. 10 Phenome-wide scans for established drug targets
  11. 11 Take-home message

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