Completed
CHIP associates with increased disease risk
Class Central Classrooms beta
YouTube videos curated by Class Central.
Classroom Contents
Clonal Hematopoiesis of Indeterminate Potential and DNA Methylation in Aging and Disease
Automatically move to the next video in the Classroom when playback concludes
- 1 Intro
- 2 Role of DNAm in gene regulation
- 3 Role of DNAm in cell fate determination
- 4 Detection of clonal hematopoiesis
- 5 CHIP associates with increased disease risk
- 6 Clonal hematopoiesis: much remains unknown about underlying mechanisms
- 7 Background: TOPMed WGS data
- 8 Discovery and replication samples
- 9 Epigenome-wide association studies (EWAS)
- 10 Example EWAS: DNAm in aging
- 11 EWAS for clonal hematopoiesis
- 12 Cell type proportions estimated from DNAM data
- 13 Reference-based approaches often used with blood
- 14 DNMT3A and TET2 EWAS profiles: what do they tell us?
- 15 Are CHIP-associated CpGs in regions of chromatin accessibility?
- 16 Enrichment for HSC gene expression signatures
- 17 Conclusions: How do CHIP mutations lead to clonality?
