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Clonal Hematopoiesis of Indeterminate Potential and DNA Methylation in Aging and Disease
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- 1 Intro
- 2 Role of DNAm in gene regulation
- 3 Role of DNAm in cell fate determination
- 4 Detection of clonal hematopoiesis
- 5 CHIP associates with increased disease risk
- 6 Clonal hematopoiesis: much remains unknown about underlying mechanisms
- 7 Background: TOPMed WGS data
- 8 Discovery and replication samples
- 9 Epigenome-wide association studies (EWAS)
- 10 Example EWAS: DNAm in aging
- 11 EWAS for clonal hematopoiesis
- 12 Cell type proportions estimated from DNAM data
- 13 Reference-based approaches often used with blood
- 14 DNMT3A and TET2 EWAS profiles: what do they tell us?
- 15 Are CHIP-associated CpGs in regions of chromatin accessibility?
- 16 Enrichment for HSC gene expression signatures
- 17 Conclusions: How do CHIP mutations lead to clonality?
