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The Johns Hopkins approach to clinical heterogeneity of various diseases: PMCOEs supported by inHealth
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Classroom Contents
Schizoaffective Disorders Precision Medicine - Heterogeneity in Schizophrenia
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- 1 Intro
- 2 The challenge: Heterogeneity in schizophrenia
- 3 Approaches to schizophrenia heterogeneity Heterogeneity based on clinical phenotype
- 4 Heterogeneity based on treatment response (Hypothesis developed at Hopkins by Fred Nucifora)
- 5 Challenges for TRS and UTRS patients
- 6 The Johns Hopkins approach to clinical heterogeneity of various diseases: PMCOEs supported by inHealth
- 7 Limitations of Precision Psychiatry
- 8 Meaning of "schizoaffective" in our PMCOE
- 9 PMCOE Organization
- 10 Guiding Hypotheses of the PMCOE
- 11 PMCOE Levels of analysis
- 12 Clinical Component of PMCOE
- 13 Johns Hopkins Schizophrenia Patient Populations
- 14 Clinical Assessment Protocol
- 15 Clinical Questions to be addressed
- 16 Mining the EMR for clinical insight
- 17 Circuitry Projects
- 18 Thalamo-cortical connectivity abnormalities in scz/scz-aff detected with 7T MRI
- 19 Challenges of thalamocortical imaging
- 20 Solving the problem of cortical layers
- 21 Hua group: vascular imaging
- 22 Circuitry as probed electrophysiologically (EEG)
- 23 Cell pathology: protein aggregation
- 24 Insoluble protein detected in -1/3 of post- mortem scz post-mortem brains
- 25 Detecting insoluble protein in cells
- 26 Extracellular vesicles (Evs): An alternative approach to exploring pathogenic markers in patient cells
- 27 Extracellular vesicles: Detection in blood by Gerber Lab
- 28 Approach to CUL1: cell and mouse models
- 29 ANK3: a gene linked to mood disorder
- 30 Schizoaffective Disorder PMCOE Projects
