Schizoaffective Disorders Precision Medicine - Heterogeneity in Schizophrenia

Schizoaffective Disorders Precision Medicine - Heterogeneity in Schizophrenia

Johns Hopkins Medicine via YouTube Direct link

Intro

1 of 30

1 of 30

Intro

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Schizoaffective Disorders Precision Medicine - Heterogeneity in Schizophrenia

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  1. 1 Intro
  2. 2 The challenge: Heterogeneity in schizophrenia
  3. 3 Approaches to schizophrenia heterogeneity Heterogeneity based on clinical phenotype
  4. 4 Heterogeneity based on treatment response (Hypothesis developed at Hopkins by Fred Nucifora)
  5. 5 Challenges for TRS and UTRS patients
  6. 6 The Johns Hopkins approach to clinical heterogeneity of various diseases: PMCOEs supported by inHealth
  7. 7 Limitations of Precision Psychiatry
  8. 8 Meaning of "schizoaffective" in our PMCOE
  9. 9 PMCOE Organization
  10. 10 Guiding Hypotheses of the PMCOE
  11. 11 PMCOE Levels of analysis
  12. 12 Clinical Component of PMCOE
  13. 13 Johns Hopkins Schizophrenia Patient Populations
  14. 14 Clinical Assessment Protocol
  15. 15 Clinical Questions to be addressed
  16. 16 Mining the EMR for clinical insight
  17. 17 Circuitry Projects
  18. 18 Thalamo-cortical connectivity abnormalities in scz/scz-aff detected with 7T MRI
  19. 19 Challenges of thalamocortical imaging
  20. 20 Solving the problem of cortical layers
  21. 21 Hua group: vascular imaging
  22. 22 Circuitry as probed electrophysiologically (EEG)
  23. 23 Cell pathology: protein aggregation
  24. 24 Insoluble protein detected in -1/3 of post- mortem scz post-mortem brains
  25. 25 Detecting insoluble protein in cells
  26. 26 Extracellular vesicles (Evs): An alternative approach to exploring pathogenic markers in patient cells
  27. 27 Extracellular vesicles: Detection in blood by Gerber Lab
  28. 28 Approach to CUL1: cell and mouse models
  29. 29 ANK3: a gene linked to mood disorder
  30. 30 Schizoaffective Disorder PMCOE Projects

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