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Amide Proton Transfer (APT): Detecting proteins & peptides in cancer cells
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Classroom Contents
Basics of CEST Agents for Cancer and Kidney Imaging Using MRI
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- 1 Intro
- 2 Chemical Exchange Saturation Transfer (CEST) Switchable MRI contrast mechanism
- 3 One nice feature for exogenous CEST agents compared to relaxa Capability of encoding color to discriminate between agent
- 4 Amide Proton Transfer (APT): Detecting proteins & peptides in cancer cells
- 5 After initial studies, we realized we wanted larger proton chemic What is optimal for Preclinical vs Clinical scanners?
- 6 How can we use salicylic acid based IM-SHY probes medical imaging application?
- 7 CEST MRI spectra for aspirin and metabolites
- 8 Experiment 2
- 9 Another nice feature of CEST agents: the contrast is often pH sensitive contrast
- 10 One organ that is inconvenient for pH electrodes an pH measurement should be useful: Kidneys
- 11 Contrast enhanced CT urography can d functional differences but not quantify • CT is in widespread use for abdominal imaging which presents advantages.
- 12 We calibrate the ratiometric contrast using a phantom of iopamidol in human serum
- 13 One application which might benefit from pH imaging: Methyl Malonic Acidemia
- 14 Overall Summary: CEST MRI is a new tool for molecular imaging with utility for molecular and cellular imaging.
