Basics of CEST Agents for Cancer and Kidney Imaging Using MRI

Basics of CEST Agents for Cancer and Kidney Imaging Using MRI

Johns Hopkins Medicine via YouTube Direct link

Intro

1 of 14

1 of 14

Intro

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Basics of CEST Agents for Cancer and Kidney Imaging Using MRI

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  1. 1 Intro
  2. 2 Chemical Exchange Saturation Transfer (CEST) Switchable MRI contrast mechanism
  3. 3 One nice feature for exogenous CEST agents compared to relaxa Capability of encoding color to discriminate between agent
  4. 4 Amide Proton Transfer (APT): Detecting proteins & peptides in cancer cells
  5. 5 After initial studies, we realized we wanted larger proton chemic What is optimal for Preclinical vs Clinical scanners?
  6. 6 How can we use salicylic acid based IM-SHY probes medical imaging application?
  7. 7 CEST MRI spectra for aspirin and metabolites
  8. 8 Experiment 2
  9. 9 Another nice feature of CEST agents: the contrast is often pH sensitive contrast
  10. 10 One organ that is inconvenient for pH electrodes an pH measurement should be useful: Kidneys
  11. 11 Contrast enhanced CT urography can d functional differences but not quantify • CT is in widespread use for abdominal imaging which presents advantages.
  12. 12 We calibrate the ratiometric contrast using a phantom of iopamidol in human serum
  13. 13 One application which might benefit from pH imaging: Methyl Malonic Acidemia
  14. 14 Overall Summary: CEST MRI is a new tool for molecular imaging with utility for molecular and cellular imaging.

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