Explore the latest developments in cancer genomics and their impact on treatment approaches in this lecture by Dr. James Ford, a Stanford Cancer Institute researcher and oncologist. Gain insights into personalized medicine, precision oncology, and targeted therapies. Understand the role of tumor profiling and genomic testing in guiding treatment decisions. Learn about the new paradigm in cancer treatment, including basket trials and umbrella protocols. Discover the challenges and opportunities in cancer genomic medicine, such as tumor heterogeneity and exceptional responses. Examine real-world case studies, including a colon cancer patient's partial response to an AKT-inhibitor in a genomic basket trial. Delve into key concepts like driver mutations and the workflow of Stanford's Molecular Tumor Board. Acquire knowledge about clinical outcomes from cohort studies and explore general resources for cancer information.
Overview
Syllabus
Intro
Stanford Cancer Institute
Personalized Medicine
Opportunities to Increase Cancer Survival
Precision Medicine in Cancer. Tumor Profiling and Therapeutics
New Paradigm in Cancer Treatment: Targeted Therapy
Cancer Genomic Profiling and Treatment: A New Paradigm
Genomic Profiling: What to Expect
"Actionable" mutations
Stanford Molecular Tumor Board Workflow
Genomic testing for patients: example report
Challenges: Cancer Genomic Medicine
Tumor Heterogeneity
Exceptional Responses
Key Concept: DRIVER mutations
Basket Trials
Umbrella Protocol 4 basket studies - early results
NCI-MATCH Schema
Clinical Outcomes: Intermountain Cohort Study
Cancer Genomics Tumor Board Case
Patient Case: Colon Cancer
Partial Response to AKT-inhibitor on genomic basket trial
Other general resources for your cancer information search
Taught by
Stanford Health Care
