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Explore the fascinating world of brain morphology in this 50-minute lecture that investigates why human brains and those of large mammals have distinct folding patterns while smaller mammals do not. Discover how mathematical models can explain the emergence of these complex convolutions during brain development and their potential pathological implications. Learn from Professor Alain Goriely, Director of the Oxford Centre for Industrial and Applied Mathematics and Fellow of the Royal Society, as he delves into fundamental questions about brain geometry: the mechanisms behind fold formation, their structural arrangement, and what these patterns reveal about brain development. Delivered at London's Barnard's Inn Hall, this Gresham College lecture offers valuable insights into the intersection of neuroscience, geometry, and developmental biology.