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Explore the performance capabilities of C and C++ programming languages and discover when Assembly language becomes necessary for optimal code efficiency. Delve into how GCC and Clang compilers generate code for various C and C++ constructs and learn techniques to enhance code performance. Examine x86-64-specific code optimizations, understand how x86-64 executes code and interacts with memory, and investigate compiler optimizations and extensions. Compare the efficiency of x86-64 assembly to C in certain scenarios, and address challenges in multi-core system programming. Gain insights into Spectre mitigations in modern compilers and the applications of profiler-guided optimizations. This 46-minute conference talk, presented by Alexander Krizhanovsky at linux.conf.au 2022, offers a comprehensive look at advanced programming techniques with numerous microbenchmarks to illustrate key concepts.