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Explore the world's most excruciating medical conditions in this 12-minute video from SciShow. Delve into the mysteries of trigeminal neuralgia, thunderclap headaches, and jackhammer esophagus, conditions that push the boundaries of human pain tolerance. Learn about these debilitating diseases, their symptoms, and the challenges in understanding their root causes. Gain insights into the complexities of pain management and the ongoing research efforts to provide relief for those suffering from these extreme forms of discomfort.