Overview
Syllabus
Intro
Overview
Laboratory-confirmed cryptococcosis in SA GERMS
Burden of cryptococcal meningitis (Gauteng Province)
Case fatality rate: South Africa
CrAg Lateral Flow Assay
Implementation and challenges
ORCAS trial
Open label RCT in Vietnam (n = 299)
WHO Guidelines 2011
Case scenario
IRIS meta-analysis
Trials of ART timing in cryptococcal meningitis prior to the COAT trial
Randomized Strategy Trial Cryptococcal Optimal ART Timing (COAT) Trial Uganda and South Africa
COAT Trial Treatment for Cryptococcal Meningitis
Causes of death
Early ART initiation particularly harmful if
What was cause of excess mortality with early ART in COAT/Zimbabwe trial?
Day 14 CSF findings
Conclusions (1)
Conclusions (2)
Acknowledgements
Taught by
Harvard University