Understanding the Role of Alzheimer's Disease Pathologies in Spatial Memory Dysfunction

Explore the impact of Alzheimer's disease pathologies on spatial memory dysfunction in this 31-minute webinar presented by Dr. Abid Hussaini, Assistant Professor at Columbia University Irving Medical Center. Delve into the vulnerability of the entorhinal cortex-hippocampal circuit to Alzheimer's disease and its effects on learning and memory. Discover how amyloid beta and tau pathologies influence neuronal and network function, particularly focusing on place cells and grid cells as neural correlates of spatial memory. Learn about cutting-edge research using mouse models, in vivo electrophysiology, optogenetics, and chemogenetics techniques to identify neurons most affected by Alzheimer's pathology. Gain insights into the relationship between neuronal activity and disease progression, and explore potential strategies for rescuing neurodegeneration through activity modulation. Earn PACE credits by watching this informative presentation, which offers valuable knowledge for researchers and healthcare professionals in the field of neurodegenerative diseases.