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Learn about tumor lysis syndrome (TLS) in this comprehensive 31-minute video lecture by Dr. Andrew L. Hong for OPENPediatrics. Explore the fundamentals of TLS, including key laboratory and clinical findings, prevention strategies, and management techniques for hyperuricemia and electrolyte abnormalities. Identify risk factors associated with this syndrome and gain practical insights through two detailed case studies. Delve into topics such as hyperkalemia, T-cell leukemia, patient evaluation, communication strategies, and medical interventions. This peer-reviewed, open-access educational resource is part of OPENPediatrics' interactive digital learning platform, designed to facilitate knowledge exchange among healthcare providers worldwide who care for critically ill children in various resource settings.