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Explore a groundbreaking approach to integrating Node.js and the Common Language Runtime (CLR) in this JSConf 2014 talk. Discover how to script C# from Node.js across Windows, Mac, and Linux platforms, combining the strengths of V8's single-threaded model with CLR's multi-threaded capabilities. Learn to leverage the vast ecosystems of both technologies, accessing over 70,000 NPM packages and 20,000 NuGet modules within a single application. Dive into Edge.js, a powerful tool that enables seamless interaction between Node.js and .NET Framework, pushing the boundaries of what's possible in modern software development.