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Explore the inner workings of the US Department of Health and Human Services through a captivating conversation featuring three former and current Secretaries from both political parties. Gain insights into the challenges of leading a $1.65 trillion agency responsible for crucial programs like Medicare, Medicaid, and various public health initiatives. Learn about the decision-making processes, priority-setting strategies, and interactions with Congress, the White House, and the American public. Discover how these leaders navigate complex issues such as promoting scientific research, expanding health insurance access, addressing public health emergencies, combating poverty and hunger, and creating workforce training opportunities. This thought-provoking discussion, moderated by Julie Rovner and featuring Xavier Becerra, Kathleen Sebelius, and Alex Azar, was part of the Aspen Ideas: Health 2023 event, offering a unique perspective on the complexities of managing one of the most influential government agencies in the United States.