The Role of Matrix Stiffness in Esophageal Cancer - Mechanism to Translational Therapeutics

Explore the impact of extracellular matrix stiffness on esophageal adenocarcinoma progression and treatment in this 47-minute seminar. Delve into the design of an engineered hydrogel platform used to culture 3D cancer organoids and investigate the mechanisms behind the disease. Learn how this innovative approach led to the identification of potential therapeutic targets activated by matrix stiffness in patient-derived organoids. Discover the potential applications of this modular hydrogel system for studying other human diseases through 3D organoid models.